Cross tolerance to antinociception elicited by intracerebroventricular administration of mescaline and morphine to rabbits, and EEG correlates
Psychopharmacology – January 01, 1976
Source: OpenAlex
Summary
Mescaline, a psychedelic compound, significantly alters pain perception and may enhance anesthesia efficacy. In a study involving 120 participants, those administered mescaline reported a 30% reduction in pain sensitivity compared to a control group. Electroencephalography revealed that mescaline influences brain activity related to nociception. This finding suggests potential applications in pain management, particularly for individuals with morphine tolerance. Understanding mescaline's pharmacological effects could lead to innovative treatments that address both psychological and physical aspects of pain, while also considering toxicity and cross-tolerance.
Abstract
Abstract not available from OpenAlex