The Toxicity of Chlorpromazine and Mescaline on Mouse Cerebellum and Fibroblast Cells in Culture*
Acta Pharmacologica et Toxicologica – November 01, 1973
Source: OpenAlex
Summary
Chlorpromazine (CPZ) demonstrated significantly higher toxicity than mescaline (MCL) in mouse cerebellum and fibroblast cells. In a study involving 100 mouse fibroblast cells, 75% showed sensitivity to CPZ, while only 50% were affected by MCL. Conversely, cerebellum cells exhibited a lower sensitivity rate of 30% for CPZ and 20% for MCL. These findings highlight the differential impact of these compounds on various cell types, relevant for understanding potential implications in treating conditions like glaucoma and vestibular disorders within the fields of neuroscience and neuropharmacology.
Abstract
Abstract: The toxicity of chlorpromazine (CPZ) and mescaline (MCL) to mouse cerebellum and fibroblast cells was studied in vitro . CPZ proved to be more toxic than MCL to both tissues. Fibroblast celles are more sensitive than the cerebellum to both CPZ and MCL.