THE EFFECT OF AN ECTOSYLVIAN EPILEPTOGENIC FOCUS INDUCED BY TOPICAL APPLICATION OF MESCALINE ON NITROGENOUS COMPOUNDS IN THE NEOCORTEX OF CAT
Journal of Neurochemistry – November 01, 1966
Source: OpenAlex
Summary
Topical application of mescaline led to significant alterations in nitrogenous compounds across the cerebral cortex. Within just 2 minutes, ammonia levels surged, particularly at the neocortical focus and adjacent marginal gyrus. By 30 minutes, ammonia remained elevated while free amide nitrogen decreased in all areas. Notably, protein nitrogen dropped in both marginal gyri, alongside lipid nitrogen reductions in the epileptical focus. These findings highlight mescaline's profound impact on brain chemistry and its potential implications for understanding memory and neural mechanisms in neuroscience.
Abstract
SUMMARY An cctosylvian spiking focus, induced by topical application of mescaline, brought about changes in nitrogenous compounds not only in the focus but throughout the cerebral cortex. Prior to the onset of the spiking focus, 2 min after mescaline application, ammonia levels increased significantly in all neocortical areas, especially at the focus and homolateral marginal gyrus; free amide nitrogen decreased and non‐protein nitrogen increased throughout the cortex. During the development of the focus–at 30 min–the ammonia level still remained high, with a tendency to decrease, and free amide nitrogen was decreased in all neocortical areas. A decrease in‘protein nitrogen’in marginal gyri, on either side and in lipid nitrogen in the epileptical focus as well as in both marginal gyri was also noted.