Nutmeg as a Narcotic. A Contribution to the Chemistry and Pharmacology of Nutmeg (Myristica fragrans)
Angewandte Chemie International Edition in English – June 01, 1971
Source: OpenAlex
Summary
Nutmeg, often overlooked, has garnered attention for its potential as a narcotic due to psychotropic compounds resembling mescaline and amphetamine. In a detailed examination of nutmeg's chemical properties, several allylbenzene derivatives were identified, indicating a possible link to hallucinogenic effects similar to LSD. With a focus on the pharmacology of Myristica fragrans, these findings highlight the plant’s traditional medicinal uses alongside its captivating chemistry. Understanding these compounds could reshape perceptions of nutmeg and its bioactive potential.
Abstract
Abstract The abuse of nutmeg for narcotic purposes has led to renewed chemical and pharmacological interest in this drug. Several allylbenzene derivatives whose biological transformation products have structures resembling mescaline and amphetamine have been identified as psychotropic constituents. It is suggested that the intensity of the hallucinogenic action of these compounds is due to the possibility of simulation of LSD‐like structural elements.