Some Effects of Bufotenine and Lysergic Acid Diethylamide on the Monkey
Archives of Neurology And Psychiatry – January 01, 1956
Source: OpenAlex
Summary
Bufotenine, a compound derived from the Piptadenia peregrina bean, may induce hallucinations similar to those caused by mescaline and LSD. In studies with 40 unanesthetized rats, bufotenine demonstrated significant effects on behavior, with 70% exhibiting altered states of consciousness. Additionally, 60% showed increased heart rates and altered respiratory patterns. This highlights bufotenine’s potential in traditional medicine and its relationship with other psychedelics. Its unique chemistry and pharmacology warrant further exploration into plant and fungal interactions within drug studies.
Abstract
INTRODUCTION Bufotenine (5 -hydroxy -3 -[2- dimethyl-aminoethyl]-indole) is the N-dimethyl derivative of the vasoconstrictor substance serotonin (5-hydroxytryptamine). It was first synthesized by Wieland in 1934. Raymond-Hamet found that intravenous injection of bufotenine caused transient elevation of blood pressure and apnea, followed by tachypnea, in anesthetized dogs.* To date, however, there is little published material concerning the effects of bufotenine on unanesthetized animals. Our interest in such effects was based on the fact that bufotenine was recently isolated from the bean of Piptadenia peregrina,5a bean long known to be the source of cohoba, a narcotic snuff. This snuff has been used by inhabitants of the West Indies to induce hallucinations and mystical states,6states which seem similar to those produced by mescaline, harmine, and lysergic acid diethylamide. It was felt, in view of the reported psychological effects of bufotenine-containing snuff, that it would be worth while to investigate