THE PRESERVATION OF SUBSTANCE P BY LYSERGIC ACID DIETHYLAMIDE
British Journal of Pharmacology and Chemotherapy – September 01, 1957
Source: OpenAlex
Summary
LSD significantly enhanced the guinea pig ileum's response to substance P, while showing no effect on histamine. In experiments, LSD inhibited the breakdown of substance P in brain extracts, a process unaffected by chymotrypsin. Notably, substances like morphine and mescaline did not replicate this effect. The presence of 2 bromo-LSD counteracted LSD's inhibition of substance P degradation. These findings suggest a potential link between LSD’s unique pharmacological actions and its influence on chemical reactions involving substance P in the brain.
Abstract
Lysergic acid diethylamide (LSD) potentiated the response of guinea‐pig ileum to substance P but not to histamine. It also inhibited the disappearance of substance P when incubated with guinea‐pig brain extract but not when incubated with chymotrypsin. Eserine, morphine, mescaline, chlorpromazine, ergometrine, strychnine and 2 bromo‐LSD did not have this effect. Oxytocin was not destroyed by brain extract. The inhibition of the destruction of substance P by LSD could be antagonized by 2 bromo‐LSD. This effect of LSD may have some relation to its pharmacological actions.