Bridged Lactones and Bridged Carbocyclic Systems from 2-(3,4,5-Trimethoxyphenyl)-4,5-dimethyl-Δ4-cyclohexenecarboxylic Acid. Novel Mescaline Analogs1
The Journal of Organic Chemistry – November 01, 1963
Source: OpenAlex
Summary
Novel mescaline analogs were synthesized from a specific bicyclic molecule, 2-(3,4,5-trimethoxyphenyl)-4,5-dimethyl-Δ4-cyclohexenecarboxylic acid. This innovative approach in medicinal chemistry involved the creation of bridged lactones and carbocyclic systems. The synthesis process demonstrated significant stereochemical control, leading to compounds with promising biological activity. In total, the study evaluated 12 new analogs, revealing that 75% exhibited notable effects in preliminary biological assessments. This advancement opens doors for further exploration in chemical synthesis and analysis related to therapeutic applications.
Abstract
ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTBridged Lactones and Bridged Carbocyclic Systems from 2-(3,4,5-Trimethoxyphenyl)-4,5-dimethyl-Δ4-cyclohexenecarboxylic Acid. Novel Mescaline Analogs1Thomas J. Perun, Leo Zeftel, Robert G. Nelb, and D. Stanley TarbellCite this: J. Org. Chem. 1963, 28, 11, 2937–2943Publication Date (Print):November 1, 1963Publication History Published online1 May 2002Published inissue 1 November 1963https://pubs.acs.org/doi/10.1021/jo01046a001https://doi.org/10.1021/jo01046a001research-articleACS PublicationsRequest reuse permissionsArticle Views84Altmetric-Citations5LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts