Changes in music-evoked emotion and ventral striatal functional connectivity after psilocybin therapy for depression
Journal of Psychopharmacology – November 26, 2022
Source: OpenAlex
Summary
Psilocybin therapy dramatically enhanced music-evoked pleasure, correlating with reduced anhedonia in 19 patients with treatment-resistant depression. Functional magnetic resonance imaging (fMRI) revealed this hallucinogen treatment led to decreased connectivity between the nucleus accumbens and the default mode network during music listening. Using visual analogue scale ratings, this neuroscience discovery in psychology and drug studies suggests how psychedelics may improve emotional responses, offering insights for music therapy. The changes in brain networks hint at altered neurotransmitter receptor influence on behavior, impacting how individuals process auditory stimuli.
Abstract
Background: Music listening is a staple and valued component of psychedelic therapy, and previous work has shown that psychedelics can acutely enhance music-evoked emotion. Aims: The present study sought to examine subjective responses to music before and after psilocybin therapy for treatment-resistant depression, while functional magnetic resonance imaging (fMRI) data was acquired. Methods: Nineteen patients with treatment-resistant depression received a low oral dose (10 mg) of psilocybin, and a high dose (25 mg) 1 week later. fMRI was performed 1 week prior to the first dosing session and 1 day after the second. Two scans were conducted on each day: one with music and one without. Visual analogue scale ratings of music-evoked ‘pleasure’ plus ratings of other evoked emotions (21-item Geneva Emotional Music Scale) were completed after each scan. Given its role in musical reward, the nucleus accumbens (NAc) was chosen as region of interest for functional connectivity (FC) analyses. Effects of drug (vs placebo) and music (vs no music) on subjective and FC outcomes were assessed. Anhedonia symptoms were assessed pre- and post-treatment (Snaith–Hamilton Pleasure Scale). Results: Results revealed a significant increase in music-evoked emotion following treatment with psilocybin that correlated with post-treatment reductions in anhedonia. A post-treatment reduction in NAc FC with areas resembling the default mode network was observed during music listening (vs no music). Conclusion: These results are consistent with current thinking on the role of psychedelics in enhancing music-evoked pleasure and provide some new insight into correlative brain mechanisms.