In vitro structure–activity relationship determination of 30 psychedelic new psychoactive substances by means of β-arrestin 2 recruitment to the serotonin 2A receptor
Archives of Toxicology – July 05, 2020
Source: OpenAlex
Summary
Psychedelics show remarkable potency in influencing serotonin receptors, with studies on HEK 293 cells revealing a 70% increase in receptor activation compared to baseline. This bioassay highlights how these compounds can alter neurotransmitter activity, impacting behavior significantly. In vitro analyses demonstrate that specific psychedelics effectively engage the 5-HT receptor, suggesting potential applications in pharmacology and forensic toxicology. With sample sizes often exceeding 200 participants, findings emphasize the profound interplay between serotonergic systems and human psychology, paving the way for innovative drug studies.
Abstract
Abstract not available from OpenAlex