Rare but relevant: Ketamine-induced cystitis - an in-depth review for addiction medicine.
Addiction (Abingdon, England) – April 04, 2025
Source: PubMed
Summary
Long-term ketamine use can cause severe bladder damage in up to 30% of regular users. This condition, known as ketamine cystitis, causes painful urination and bladder shrinkage. Lower urinary tract symptoms often start within months of regular use, progressing to potentially irreversible ketamine uropathy if untreated. Early detection through urodynamics testing is crucial, as advanced cases may require surgery for ureteric stricture. The good news: symptoms can improve significantly with early intervention and ketamine cessation.
Abstract
Ketamine-induced cystitis is an increasingly recognized complication associated with the addictive use of ketamine, a dissociative anesthetic. This article provides a comprehensive overview, focusing on its pathophysiology, clinical presentation, diagnosis, management strategies, and implications for addiction treatment. The British Association of Urological Surgeons consensus serves as a foundational reference for management, while additional literature is integrated to highlight the multifaceted nature of Ketamine Bladder and its impact on individuals with substance use disorders.