DMT as the Prototype of a New Class of Crisis-Linked Endogenous Consciousness Modulators (cECMs)
Zenodo (CERN European Organization for Nuclear Research) – November 23, 2025
Source: OpenAlex
Summary
DMT emerges as a unique biological class of consciousness modulators, meeting all six criteria for crisis-linked endogenous consciousness modulators (cECMs). In contrast, 5-MeO-DMT meets five criteria, while classic psychedelics like psilocin and LSD fail most. This classification is backed by evidence of DMT's biosynthesis in mammalian brains and its rapid pharmacological effects. With four testable predictions outlined, the cECM model offers a precise alternative to existing psychedelic frameworks, potentially reshaping our understanding of consciousness and its neurobiological underpinnings.
Abstract
DescriptionThis preprint proposes a new biological classification for N,N-dimethyltryptamine (DMT): crisis-linked endogenous consciousness modulators (cECMs). Using six mechanistically grounded, falsifiable criteria—endogenous neural biosynthesis, deep evolutionary conservation, ultra-rapid pharmacokinetics, multi-receptor promiscuity, crisis-linked release, and induction of information-rich structured internal states—DMT is shown to uniquely satisfy all criteria. 5-MeO-DMT meets five and is designated borderline; classic psychedelics (psilocin, LSD, mescaline) and conventional neuromodulators fail most criteria. The framework is supported by published evidence of mammalian brain biosynthesis, sigma-1 receptor regulation, TAAR signaling, and ischemia-linked surges. Four concrete, testable predictions are presented. The cECM model provides a precise, predictive alternative to the current “classic psychedelic” taxonomy.