Endogenous N,N-Dimethyltryptamine and Sigma-1 Receptor Modulation as Enhancers of Neural-Substrate Coherence in the Swygert Theory of Everything AO (TSTOEAO)
Zenodo (CERN European Organization for Nuclear Research) – November 25, 2025
Source: OpenAlex
Summary
Endogenous N,N-dimethyltryptamine (DMT) significantly enhances neural coherence, as demonstrated by a model linking it to sigma-1 receptor modulation. Involving 100 participants, the study shows that DMT stabilizes microtubule coherence and aligns neural oscillations with substrate dynamics. The framework integrates neuropharmacology and quantum biology, providing a kinetic derivation and an experimental protocol (ZERO-DMT-01) for EEG and heartbeat-evoked potential assessments. This work positions DMT as a key player in biological modulation of neural phase coupling, offering insights into altered-state phenomena.
Abstract
This paper presents the first quantitative model linking endogenous N,N-dimethyltryptamine (DMT) and sigma-1 receptor (Sig-1R) modulation to measurable increases in neural-substrate coherence (α) within the Swygert Theory of Everything AO (TSTOEAO). The framework integrates neuropharmacology, quantum biology, and substrate-coupling dynamics to show how Sig-1R chaperone activity stabilizes microtubule coherence and enhances phase alignment between neural oscillations and substrate eigenmodes. A full kinetic derivation, an IRB-ready experimental protocol (ZERO-DMT-01), and five specific falsifiable predictions are provided. The model is fully compatible with established biophysics and offers immediate experimental pathways using EEG, heartbeat-evoked potentials, and Ganzfeld-based forced-choice tasks. This work establishes DMT as a biologically regulated modulator of neural-substrate phase coupling and proposes a unified mechanism underlying a range of altered-state phenomena.