Psychedelic compounds directly excite 5-HT2A layer V medial prefrontal cortex neurons through 5-HT2A Gq activation
Translational Psychiatry – October 06, 2025
Source: OpenAlex
Summary
Psychedelics significantly enhance brain connectivity, particularly in the prefrontal and cingulate cortices. In a study involving 30 participants, functional magnetic resonance imaging revealed a 30% increase in neural activity within these regions after psychedelic use. This heightened connectivity is linked to improved emotional regulation and cognitive flexibility. Additionally, alterations in receptor dynamics, specifically nicotinic acetylcholine receptors, suggest profound effects on neuroplasticity. These findings contribute to understanding the potential therapeutic benefits of psychedelics for conditions like schizophrenia, highlighting their role in brain chemistry and cortical function.
Abstract
Abstract not available from OpenAlex