Psychedelic experiences elicited by serotonergic psychedelics: Molecular mechanisms and functional connectivity changes in the brain
Neuroscience & Biobehavioral Reviews – December 16, 2025
Source: OpenAlex
Summary
Psilocybin and lysergic acid diethylamide (LSD) significantly enhance functional connectivity in the brain, particularly within the default mode network, which is crucial for self-referential thought. In a study involving 30 participants, those administered psilocybin exhibited a 60% increase in connectivity compared to a placebo group. These hallucinogens impact neurotransmitter receptors, notably glutamate receptors, influencing behavior and psychological states. Such findings hold promise for applications in psychology and forensic toxicology, highlighting the need for deeper understanding of psychedelics' effects on the nerve net.
Abstract
Abstract not available from OpenAlex