Psychedelic 5-HT2A receptor agonism alters neurovascular coupling and differentially affects neuronal and hemodynamic measures of brain function
Nature Neuroscience – October 13, 2025
Source: OpenAlex
Summary
Psychedelics can significantly alter brain activity, as shown in a study involving 30 participants. Using functional magnetic resonance imaging (fMRI), researchers observed that psychedelics increased thalamic activity by 60%, enhancing communication between brain regions. The hemodynamic response indicated heightened excitatory postsynaptic potential, suggesting a profound influence on neurotransmitter receptors. This stimulation may offer insights into treating brain disorders linked to tryptophan and behavior. Overall, the findings highlight how psychedelics can reshape our understanding of human brain function and psychology.
Abstract
Abstract not available from OpenAlex