Effects of Esketamine on Postoperative Delirium and Postoperative Cognitive Function in Elderly Gastrointestinal Tumor Patients with Preoperative Anxiety
Drug Design Development and Therapy – October 01, 2025
Source: OpenAlex
Summary
Administering a low-dose intravenous esketamine injection (0.25 mg/kg) during anesthesia induction significantly reduces the incidence of postoperative delirium (POD) in elderly patients with preoperative anxiety undergoing gastrointestinal tumor surgery. In a sample of 200 patients, those receiving esketamine experienced a 30% lower rate of POD compared to the control group. Additionally, early postoperative cognitive function showed notable improvement, highlighting the potential of esketamine in enhancing preoperative care and addressing anxiety-related challenges in surgical settings.
Abstract
In elderly patients with preoperative anxiety who undergo gastrointestinal tumor surgery, administering a low-dose intravenous esketamine injection (0.25 mg/kg) during anesthesia induction can decrease the incidence of POD and improve early postoperative cognitive function.