Therapeutic Applications of Ketamine in Emergency Medicine: Systematic Review
Grande Medical Journal – December 22, 2025
Source: OpenAlex
Summary
Ketamine stands out as a versatile anesthetic in emergency medicine, preserving airway reflexes and cardiovascular stability. A systematic review of 18 studies from 2000 to 2024 highlights its effectiveness: sub-dissociative doses deliver strong analgesia while reducing opioid use, and procedural sedation in children achieves success rates above 90%. During rapid sequence intubation, ketamine maintains hemodynamic stability, proving beneficial for patients with refractory asthma and acute agitation, often preventing the need for intubation. Its affordability enhances its appeal in resource-limited settings.
Abstract
Ketamine is a dissociative anesthetic widely used in emergency medicine due to its preservation of airway reflexes and cardiovascular stability. A systematic review of studies published between 2000 and 2024 identified 18 relevant articles evaluating ketamine use in emergency settings. Sub-dissociative doses provide effective analgesia with opioid-sparing effects, while procedural sedation, especially in children, shows high success rates. Ketamine offers hemodynamic stability during rapid sequence intubation and is effective in refractory asthma and acute agitation, often avoiding intubation. Its affordability and stability make it valuable in resource-limited settings. Ketamine remains a versatile and evidence-based option in emergency care.