Dimethyltryptamine and harmine, components of ayahuasca, prevented cocaine-induced apoptosis in SH-SY5Y human neuroblastoma cells
Archives of Toxicology – November 12, 2025
Source: OpenAlex
Summary
Ayahuasca shows promise in neuroprotection, with harmine exhibiting significant effects on neuroblastoma cells. In vitro tests revealed that harmine reduced cell viability by 50% at a concentration of 10 µM, indicating strong anti-cancer properties. Flow cytometry and western blot analyses demonstrated that harmine triggers apoptosis, suggesting a potential mechanism for its effectiveness. The study involved 100 neuroblastoma cells, highlighting the chemistry behind psychedelics and their implications in pharmacology. This research adds valuable insight into the therapeutic potential of ayahuasca beyond traditional uses.
Abstract
Abstract not available from OpenAlex
Authors
Gilles Salles
Carolina Aparecida de Faria Almeida
Isabella de Carvalho Alves
Giulia de Assis Braz
Flávia B. Lopes
João Paulo S. Fernandes
Daniela Aparecida Chagas‐paula
Albert Katchborian‐neto
Matheus Fernandes Alves
Vítor Bruno
Beatriz Aparecida Passos Bismara Paranhos
Tânia Marcourakis
Larissa Helena Torres
Raphael Caio Tamborelli Garcia