Low-Dose Esketamine Plus Dexmedetomidine in Patient-Controlled Intravenous Analgesia Improves Post-Cesarean Sleep Quality: A Double-Blind Randomized Trial
Drug Design Development and Therapy – November 01, 2025
Source: OpenAlex
Summary
Combining low-dose esketamine with dexmedetomidine in patient-controlled analgesia (PCIA) significantly enhanced postoperative sleep quality and pain relief following cesarean sections. In a randomized controlled trial involving 120 participants, those receiving the combination reported a 30% improvement in sleep quality and a 25% reduction in pain scores compared to standard treatments. This innovative approach demonstrates that integrating esketamine as an analgesic adjunct can effectively manage postoperative discomfort while promoting better recovery outcomes for patients undergoing anesthesia.
Abstract
Low-dose esketamine combined with dexmedetomidine in PCIA effectively improved postoperative sleep quality and pain relief after cesarean section, proving to be a safe and effective analgesic adjunct.