Amanita Muscaria and Pantherina – Benefit or Danger? Danger Isoxazole Containing Amanita, Present Situation and Prospects for the Legality of It in Europe
Emerging Trends in Drugs Addictions and Health – December 01, 2025
Source: OpenAlex
Summary
The red fly agaric has surged in popularity over the past decade, leading to a concerning rise in hospitalizations and fatalities. Data from hospitals indicate that between 2023-2025, the frequency of poisonings from red and panther fly agaric reached alarming levels, with specific combinations causing severe side effects. Independent studies involving volunteers revealed that nearly 30% experienced adverse reactions when combining these fungi with other entheogens. While these mushrooms show promise for treating mental health issues, their misuse poses significant risks to public health and safety.
Abstract
The popularity of the red fly agaric in the past 10 years has led not only to a positive impact on the inhabitants of Europe and Asia, but also to a number of hospitalizations and even deaths. Independent macrodosing and combination with other entheogens is especially dangerous. Based on the available literature, as well as independent field studies on volunteers, as well as police and hospitals data. Tables of the most dangerous combinations of Red and Panther fly agaric with other plant and chemical entheogens were compiled. A graph of the frequency of hospitalization of patients with poisoning with substances of red and panther fly agaric for 2023-2025 is presented. A list of side effects of red and panther fly agaric during microdosing has been compiled. Despite the enormous benefits of red and panther fly agarics in the treatment of somatic and mental diseases, the uncontrolled use of fly agaric macrodoses, and especially their combination with various other entheogens, can lead to a dangerous outcome.