Low-Dose Sublingual Ketamine for the Treatment of Raynaud's Phenomenon.
Cureus – January 01, 2025
Source: PubMed
Summary
Low-dose ketamine shows promise for people suffering from cold-triggered numbness and color changes in their fingers. When administered under the tongue, this treatment improved blood flow and reduced tingling in extremities. Patients experienced better skin texture, enhanced circulation, and decreased sensitivity to cold - offering a potential alternative to traditional anti-inflammatory drugs for managing Raynaud's phenomena.
Abstract
Raynaud's phenomenon is a vascular disorder characterized by episodic vasospasm of small arteries, primarily affecting the hands and feet. Standard treatment strategies typically include lifestyle modifications to avoid cold exposure and stress, alongside pharmacological interventions aimed at increasing blood flow and reducing vascular constriction. Ketamine, an FDA-approved anesthetic since 1970, exhibits analgesic and vasodilatory properties that may enhance perfusion. This case report describes a woman with primary Raynaud's phenomenon whose symptoms improved significantly during treatment with low-dose sublingual ketamine prescribed for treatment-resistant depression. Further research into the use of this safe and inexpensive medicine as a treatment for Raynaud's phenomenon is recommended.