Ex Vivo Effect of Ibogaine on the Transcriptional Level of Antioxidant Defense Related Genes in Honey Bee (Apis mellifera, L.) Midgut
Elvira Vukašinović, Jelena Purać, Danijela Kojić, Tatjana Čelić, Ivan Pihler, Duško Blagojević
Brazilian Archives of Biology and Technology January 1, 2021 Peer reviewed DOI: 10.1590/1678-4324-2021200773 via OpenAlex
Summary
Ibogain treatment leads to an increase in the expression of the Sod1 gene in honey bee midguts, indicating a pro-antioxidant effect. The honey bee midgut is identified as a suitable model for studying these antioxidative mechanisms.
Study at a glance
| Population | honey bee midguts |
|---|---|
| Key finding | Ex vivo ibogaine treatment induced an up-regulation of the Sod1 gene. |
Abstract
HIGHLIGHTS The ibogain action has not been completely clarified. Honey bee midgut is suitable model system for testing the antioxidative mechanisms. The ex vivo ibogaine treatment induced an up-regulation of Sod1 gene. Ibogaine shows pro-antioxidant action.