Effects of ibogaine per os treatment on redox homeostasis in rat kidney
Teodora Vidonja Uzelac, Nikola Tatalović, Milica Mijović, Aleksandra Nikolić‐kokić, Zorana Oreščanin-dušić, Mara Bresjanac, Duško Blagojević
Archives of Biological Sciences January 1, 2019 Peer reviewed DOI: 10.2298/abs190208006v via OpenAlex
Summary
Ibogaine administration at doses of 1 and 20 mg/kg in rats resulted in altered antioxidant enzyme activities and mild oxidative stress in the kidneys. Specifically, a 1 mg/kg dose increased superoxide dismutase (SOD1) activity while decreasing glutathione reductase (GR) activity after 6 and 24 hours. The 20 mg/kg dose also decreased GR activity, and moderate morphological changes were observed in the kidneys after 24 hours, although kidney function remained unaffected based on urinalyses. Monitoring kidney function during ibogaine use in humans is recommended.
Study at a glance
| Population | rats |
|---|---|
| Key finding | Ibogaine at 1 mg/kg increased SOD1 activity and decreased GR activity, while the 20 mg/kg dose decreased GR activity, with no measurable effects on kidney function. |
Abstract
Our previous results showed that a single oral dose (1 or 20 mg/kg body weight) of the anti-addiction agent ibogaine induced in rats 6 and 24 h after administration glycogenolytic activity in hepatocytes, followed by a mild oxidative stress. In this work, we examined the in vivo effect of the same doses of ibogaine on rat kidney morphology, antioxidant enzyme (superoxide dismutases (SOD1 and 2), catalase, glutathione peroxidase, glutathione reductase (GR) and glutathione- S-transferase) activities, and oxidative stress (TBARS) and redox (-SH groups) parameters. The dose of 1 mg/kg ibogaine induced an elevation in SOD1 activity and decreased GR activity after 6 and 24 h. GR activity was decreased at 6 and 24 h after 20 mg/kg ibogaine administration, suggesting changed redox homeostasis. After 24 h, we observed an increase in moderate morphological changes, without changes in urinalyses, indicating that kidney function was not measurably affected. Nevertheless, kidney-function monitoring during and following ibogaine use in human subjects is advisable.