Psychedelics and related compounds in cluster headache and migraine: a systematic review and meta-analysis v1
Camille Racca, Cécilie Cordier
June 21, 2026 DOI: 10.17504/protocols.io.j8nlk7ey6g5r/v1 via OpenAlex
Summary
A systematic review and meta-analysis will evaluate the efficacy and safety of classic serotonergic psychedelics and related compounds for treating cluster headache and migraine. The analysis will include clinical studies on various substances such as psilocybin, LSD, and methysergide. The goal is to synthesize evidence regarding headache burden, safety, quality of life, and functional impact, with plans for random-effects meta-analyses if enough comparable data exist.
Study at a glance
| Design | systematic review and meta-analysis |
|---|---|
| Population | clinical studies evaluating various serotonergic compounds in individuals with cluster headache and migraine |
| Key finding | The review aims to synthesize evidence on the efficacy and safety of serotonergic psychedelics for cluster headache and migraine. |
Abstract
This protocol describes a systematic review and meta-analysis assessing the efficacy and safety of classic serotonergic psychedelics and related serotonergic ergoline or lysergamide compounds in cluster headache and migraine. The review will include clinical studies evaluating psilocybin, psilocin, LSD, LSA, DMT/ayahuasca, mescaline, BOL-148 / 2-bromo-LSD / bromolysergide, lisuride, methysergide and methylergonovine. The expected result is a structured synthesis of the available evidence on changes in headache burden, safety and tolerability, quality of life, and functional impact. If sufficient comparable data are available, random-effects meta-analyses will be conducted separately according to headache disorder and compound used.