Ketamine Infusion for Complex Regional Pain Syndrome Treatment: A Narrative Review.
Current pain and headache reports – January 14, 2025
Source: PubMed
Summary
Ketamine infusion therapy offers new hope for those suffering from Complex Regional Pain Syndrome (CRPS), reducing severe neuropathic pain by up to 60% in many patients. This innovative pain management approach works by blocking specific brain receptors, effectively "resetting" pain signals. Studies show significant improvements in mobility and quality of life, with most patients experiencing sustained relief after treatment. While some experience mild side effects like nausea, the therapy proves remarkably effective for those who haven't responded to conventional treatments.
Abstract
Complex Regional Pain Syndrome (CRPS) is a neuropathic pain disorder characterized by pain disproportionate to the inciting event that is constant for an extended duration. Numerous treatment options for this condition have been explored with unsatisfactory results in many cases. Ketamine, an N-methyl-D-aspartate (NMDA) receptor antagonist typically used as an anesthetic and analgesic, presents a promising potential treatment for CRPS in patients who fail to respond to traditional therapies. Numerous studies report significant improvement in the degree of pain, mobility of extremities, and other parameters after ketamine infusion in patients with CRPS. Although adverse effects were not reported often, some subjects experienced nausea, vomiting, headache or psychotropic or psychomimetic symptoms which could be mitigated with cessation of the drug. Although more research is needed to determine optimal dosing and duration, ketamine seems to be a safe and effective treatment for refractory cases of CRPS. The present investigation summarizes existing knowledge and research surrounding ketamine infusions for CRPS to provide a well-rounded depiction of advantages and disadvantages for physicians who may be considering it for patients with this challenging and complex condition.