Mammalian Biosynthesis of Potential Psychotogens Derived from Dopamine
Arnold J. Friedhoff, Jack W. Schweitzer
Catecholamines and Behavior · 1 January 1, 1975 DOI: 10.1007/978-1-4684-3135-3_7 via Springer Nature
Summary
Hallucinogens impair higher brain centers without substantially affecting other central nervous system functions. The structural resemblance between certain hallucinogens and several central nervous system transmitters has been noted: mescaline resembles dopamine, while N,N-dimethyltryptamine and bufotenin resemble serotonin. The hallucinogenic properties of these biogenic amine congeners are well documented for mescaline and the indoles.
Study at a glance
| Characteristics | Review Peer reviewed |
|---|---|
| Keywords | Biogenic amine Comt activity Catecholamine metabolite Cetic acid Hallucinogenic property |
| Citations | 1 |
| Key finding | Hallucinogens impair higher brain centers without substantially affecting other central nervous system functions, and their structural resemblance to neurotransmitters like dopamine and serotonin is well documented. |
Abstract
Normal mental functions can be disrupted by many kinds of drugs. Hallucinogens are of special interest because of their ability to impair higher centers without producing substantial effect on other functions of the central nervous system. While the mechanism of action of hallucinogens has not been clarified, the striking structural resemblance between certain of these agents and several central nervous system transmitters has not gone unnoticed (Osmond and Smythies, 1952; Snyder and Merril, 1965). Mescaline, for example, bears a strong structural similarity to dopamine, and, among indoles, N,N -dimethyltryptamine and bufotenin resemble serotonin (Figure 1). The hallucinogenic properties of these biogenic amine congeners are well documented for mescaline (Kapadia and Fayez, 1970) and for the indoles (Fujimori and Alpers, 1970).