Combined Low Dose of Ketamine and Social Isolation: A Possible Model of Induced Chronic Schizophrenia-Like Symptoms

Summary

Combining ketamine with social isolation in male albino rats produces long-lasting behavioral and neurochemical deficits that resemble schizophrenia, offering a potential model for studying the disorder's multifactorial origins. Rats given ketamine and isolated showed fewer line crossings in an open field test, fewer open arm entries in an elevated plus maze, and lower spontaneous alternation in a Y-maze compared to controls and ketamine-treated rats housed socially. The combined intervention also increased malondialdehyde (MDA) levels and decreased glutathione peroxidase (GPx) levels in the hippocampus and cortex, indicating oxidative stress. Adding aripiprazole helped model both positive and negative symptoms.

Study at a glance

Abstract

Introduction Identifying a feasible model of chronic schizophrenia would be valuable for studying the possible underlying mechanism and to investigate emerging treatments. Our hypothesis starts from the observation that combining ketamine with isolation could result in long-lasting neuro-psychological deficits and schizophrenia-like features; thus, it could probably be used as the first model of chronic schizophrenia that emphasizes the characteristic of having a multifactorial etiology Objectives creation of a complex animal model capable of exhibiting the multifactorial origin and manifestation of schizophrenia. Methods we investigated the effects of ketamine administration combined with isolation in inducing schizophrenia-like symptoms in male albino rats and the brain reactive oxygen species levels. Results Our results showed that the number of lines crossings in the open field test, the number of open arm entries in the elevated plus maze, and the spontaneous alternations percentage in the Y-maze were significantly lower in the ketamine + isolation group compared to both the control and ketamine + social housing group (p < 0.05). Furthermore, the ketamine + isolation intervention significantly increased the MDA levels and decreased the GPx levels both in the hippocampus and the cortex of the rats. In addition, our premise of creating a model capable of exhibiting both positive and negative symptoms of schizophrenia was also based on adding the aripiprazole treatment to a group of rats Conclusions combining ketamine with isolation could result in long-lasting neuro-psychological deficits and schizophrenia-like features Disclosure No significant relationships.