ChemInform Abstract: CONFORMATIONALLY CONSTRAINED ANALOGS OF MESCALINE
R. J. Wolters, A. J. Bej, N. S. Tanner
Chemischer Informationsdienst January 14, 1975 DOI: 10.1002/chin.197502303
Summary
A chemical reaction converts 3,4,5-trimethoxyphenylacetonitrile (I) with bromopropionitrile in the presence of sodium hydride in dimethylformamide to yield a glutaronitrile derivative (II) in 50% yield. Subsequent alkaline hydrolysis of (II) produces a glutaric acid derivative (III) in 77% yield.
Study at a glance
| Characteristics | Peer reviewed |
|---|---|
| Key finding | The reaction sequence produces a glutaric acid derivative from 3,4,5-trimethoxyphenylacetonitrile in two steps with overall yields of 50% and 77%. |
Abstract
Abstract3,4,5‐Trimethoxyphenylacetonitril (I) reagiert mit Brompropionitril in Gegenwart von Natriumhydrid in Dimethylformamid in 50%iger Ausbeute zum Glutarsäuredinitrilderivat (II), dessen alkalische Hydrolyse in 77%iger Ausbeute zum Glutarsäurederivat (III) führt.