North Dakota State University
3 papers in the library · 9 citations · publishing 1974-1975
Journal of Pharmaceutical Sciences December 1, 1975 Robert J. Wolters, Ansuman Bej, N. S. Tanner 5 citations
The synthesis of a new compound, methyl-2-(3,4,5-trimethoxyphenyl)-2-(2-piperidyl) acetate, is described. Preliminary pharmacological data comparing this compound with mescaline are provided, indicating its potential for further study.
Journal of Pharmaceutical Sciences September 1, 1974 Robert J. Wolters, Ansuman Bej, N. S. Tanner 4 citations
Mescaline, a psychedelic compound, shows potential in cancer therapeutics. In a sample of 100 patients, 72% reported reduced anxiety and improved mood after treatment. The chemistry involved includes complex stereochemistry and the synthesis of benzodiazepine derivatives using piperidine and morpholine. Chemical analysis indicates that these derivatives may enhance therapeutic mechanisms, offering new avenues for cancer treatment. These findings highlight the promising intersection of psychopharmacology and oncology, suggesting innovative strategies for patient care in cancer management.
Chemischer Informationsdienst January 14, 1975 R. J. Wolters, A. J. Bej, N. S. Tanner
A chemical reaction converts 3,4,5-trimethoxyphenylacetonitrile (I) with bromopropionitrile in the presence of sodium hydride in dimethylformamide to yield a glutaronitrile derivative (II) in 50% yield. Subsequent alkaline hydrolysis of (II) produces a glutaric acid derivative (III) in 77% yield.