Sphincter of oddi dysfunction induced by ketamine: A case report.
Clinical case reports – June 01, 2024
Source: PubMed
Summary
Long-term ketamine abuse, even at low doses, can disrupt a crucial muscle controlling bile flow in the digestive system. A recent medical case revealed how a young woman's recreational drug use led to severe abdominal pain from sphincter of oddi dysfunction. Early detection and stopping ketamine use resolved her biliary disease symptoms, highlighting the importance of considering drug abuse history when diagnosing unexplained digestive problems.
Abstract
Chronic ketamine use can lead to sphincter of oddi dysfunction (SOD), causing various hepatobiliary complications. Recognizing substance abuse history is vital for early detection. Timely intervention can prevent irreversible liver and pancreas damage. Ketamine is commonly abused as a recreational drug worldwide due to its ability to induce euphoria-like effects. Ketamine abuse is associated with many hepatobiliary side effects ranging from cholestasis to biliary sepsis and death. Here we present a case of a young 29-year female with upper abdominal pain due to SOD resulting from chronic use of ketamine. SOD can result in obstruction or dysfunction of the bile and pancreatic ducts. Ketamine induces SOD by activation of the muscarinic receptors in the sphincter of oddi. Detail history of substance abuse is crucial for early identification of ketamine-induced SOD. Early identification and treatment of this rare condition can prevent permanent injury to the liver and pancreas.