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Ketamine as a Treatment Option for Severe Borderline Personality Disorder

Helena Rogg, Mihai Avram, Felix Müller, Klaus Junghanns, Stefan Borgwardt, Bartosz Zurowski

Journal of Clinical Psychopharmacology December 30, 2022 DOI: 10.1097/jcp.0000000000001642 via OpenAlex

Summary

Ketamine treatment in patients with borderline personality disorder (BPD) may reduce symptom severity, but the evidence is preliminary and based on small samples. The review suggests that ketamine could be a potential therapeutic option for BPD, particularly for comorbid depression, though more rigorous studies are needed to confirm efficacy and safety. The authors note that existing studies have significant limitations, including lack of control groups and short follow-up periods.

Study at a glance

Characteristics Review Peer reviewed
Intervention Ketamine
Topics Ketamine
Keywords Borderline personality disorder Psychology Psychoanalysis Psychotherapist
Citations 8
Key finding Ketamine may reduce symptom severity in borderline personality disorder, but evidence is preliminary and limited.

Abstract

Rogg, Helena MD; Avram, Mihai PhD; Müller, Felix MD; Junghanns, Klaus MD; Borgwardt, Stefan MD; Zurowski, Bartosz MD Author Information

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