Ketamine in Bipolar Disorder: A Review
Alina Wilkowska, Łukasz P. Szałach, Wiesław Jerzy Cubała
Neuropsychiatric Disease and Treatment November 1, 2020 DOI: 10.2147/ndt.s282208 via OpenAlex
Summary
Bipolar disorder is a psychiatric illness with high morbidity, mortality, and suicide rates, a neuroprogressive course, and frequent treatment resistance, creating a need for new treatment strategies. Ketamine appears to have rapid antidepressive and antisuicidal effects. Because most available studies concern unipolar depression, this article presents a novel argument that ketamine might be a promising treatment for bipolar disorder.
Study at a glance
| Characteristics | Theoretical or philosophical paper Peer reviewed |
|---|---|
| Topics | Depression Ketamine |
| Keywords | Medicine Bipolar disorder Depression economics Psychiatry |
| Citations | 31 |
| Key finding | Ketamine might be a promising treatment for bipolar disorder. |
Abstract
Abstract: Bipolar disorder (BD) is a psychiatric illness associated with high morbidity, mortality and suicide rate. It has neuroprogressive course and a high rate of treatment resistance. Hence, there is an unquestionable need for new BD treatment strategies. Ketamine appears to have rapid antidepressive and antisuicidal effects. Since most of the available studies concern unipolar depression, here we present a novel insight arguing that ketamine might be a promising treatment for bipolar disorder. Keywords: ketamine, bipolar disorder, staging, neuroprogression, treatment resistance