Evaluation of Histopathologic Findings and Safety of Intravitreal Ketamine Administration on Vitreoretinal Tissue in Rat Model: A Pilot Study.
Journal of current ophthalmology – January 01, 2023
Source: PubMed
Summary
Ketamine, known for its anesthetic properties, shows promising safety when administered directly into the eye. In a groundbreaking investigation, researchers tested intravitreal ketamine injections in rats, monitoring eye tissue health. After one month, the treated eyes showed no signs of damage, inflammation, or adverse effects on the retina or optic nerve - suggesting this could be a safe approach for future eye treatments.
Abstract
To evaluate the safety and histological findings of intravitreal injection of ketamine in rats. Each rat received a total volume of 0.1 ml of ketamine 0.01 mol/L (5 rats as ketamine group) or a total of 0.1 ml of normal saline 0.9% (5 rats as control group) under general anesthesia in a sterile condition. A histology assessment was performed 1 month after the intravitreal injection. Lens opacity, necrosis, and atrophy of retinal layers and optic disc were not seen in five specimens in the ketamine group and five in the normal saline group. There was no inflammation in the vitreous, retinal layers, choroid, optic disc, and optic nerve in both groups. Intravitreal injection of ketamine in a special dose has no obvious adverse effect on diverse intraocular tissue.