Comparison of Haloperidol and Chlorpromazine in the Treatment of Phencyclidine Psychosis
A. James Giannini, Michael S. Eighan, Robert H. Loiselle, Matthew C. Giannini
The Journal of Clinical Pharmacology April 1, 1984 DOI: 10.1002/j.1552-4604.1984.tb01831.x
Summary
AI-generated from the abstractHaloperidol and chlorpromazine are both effective for treating phencyclidine (PCP) psychosis, likely by blocking central dopamine receptors. While their effects have been studied extensively in animals and less so in humans, no prior comparison of their relative effects in human populations existed. This study provides that comparison.
Study at a glance
| Characteristics | Comparative study Peer reviewed |
|---|---|
| Population | Human populations |
| Interventions | Haloperidol Chlorpromazine |
| Key finding | Haloperidol and chlorpromazine are both effective in treating PCP psychosis, but their relative effects in humans had not been compared before this study. |
Abstract
Two neuroleptics, haloperidol and chlorpromazine, have been reported to be effective in the treatment of phencyclidine (PCP) psychosis. Both neuroleptics are thought to exert their antipsychotic PCP effects by blockade of central dopamine receptors. They have been studied extensively in animal populations and less extensively in human populations. There has, however, been no comparison of their relative effects in human populations. We describe such a study below.