Randomized Trial of Ketamine Masked by Surgical Anesthesia in Depressed Patients
medRxiv Preprint Server – April 28, 2023
Source: medRxiv
Summary
Could a powerful antidepressant work without patients experiencing its typical effects? Researchers explored if ketamine, known for its rapid antidepressant properties, could alleviate severe depression symptoms when given during general anesthesia. This innovative approach aimed to ensure true blinding. Findings revealed that patients receiving the medication experienced significant and sustained mood improvement, highlighting its potential as an effective treatment.
Abstract
BACKGROUND Ketamine may have antidepressant properties, but its acute psychoactive effects complicate successful masking in placebo-controlled trials.