Ketamine induces multiple individually distinct whole-brain functional connectivity signatures
bioRxiv Preprint Server – November 01, 2022
Source: bioRxiv
Summary
Intriguingly, ketamine reshapes how different brain areas connect and work together, uniquely for each individual. Researchers observed this promising therapy creates distinct whole-brain activity patterns using advanced imaging. This discovery highlights how ketamine’s personalized impact on neural networks can explain varied therapeutic responses.
Abstract
Ketamine has emerged as one of the most promising therapies for treatment-resistant depression. However, inter-individual variability in response to ketamine is still not well understood and it is unclear how ketamine’s molecular mechanisms connect to its neural and behavioral effects.
Authors
Flora Moujaes
Jie Lisa Ji
Masih Rahmati
Joshua Burt
Charles H. Schleifer
Brendan Adkinson
Aleksandar Savič
Nicole Santamauro
Zailyn Tamayo
Caroline Diehl
Antonija Kolobaric
Morgan Flynn
Nathalie M. Rieser
Clara Fonteneau
Terry Camarro
Junqian Xu
Youngsun T. Cho
Grega Repovš
Sarah K. Fineberg
Peter Morgan
Erich Seifritz
Franz X. Vollenweider
John Krystal
John D. Murray
Katrin H. Preller
Alan Anticevic