Underground small-group therapy of treatment-resistant depression and complex post-traumatic stress disorder (C-PTSD) with psilocybin—A retrospective case study
OpenAlex – March 10, 2023
Source: OpenAlex
Summary
A woman with 30 years of treatment-resistant depression found lasting relief through psilocybin. After prior medications caused adverse effects and discontinuation, she engaged in six psilocybin sessions over 1.5 years. This approach in clinical psychology helped interrupt dissociative trauma responses. A 2.5-year follow-up confirmed remission, suggesting a multi-dose strategy with psychedelics can offer profound psychological healing. This case highlights how psilocybin, an alkaloid influencing neurotransmitter receptors, may resolve severe depression where traditional psychiatry failed, particularly for those experiencing early life trauma and feelings of abandonment.
Abstract
While a relatively large body of research exists on many aspects of psychedelic therapy, articles describing a complete, successful treatment process are rarely found. This article therefore presents a case of a woman in her early forties with early complex trauma due to domestic violence, sexual abuse and poverty in her childhood, resulting in approximately three decades of treatment resistant depression. Antidepressive medications did not alleviate her depression but resulted in adverse effects and an eventual discontinuation of the medications. Eventually the woman resorted to 'mixed-method' underground small-group sessions that utilized breathing exercises, cold exposure, physical exercises, music, and psilocybin mushrooms. Psilocybin appeared to interrupt trauma-related dissociation, producing an 'anti-dissociative' effect, allowing the woman to re-experience, in a controlled setting, dissociated physical sensations produced by earlier overwhelming events. After a period of approximately 1.5 years, during which time she had six psilocybin sessions, either individually, in the small group, or with friends, she achieved a remission of her depression. A follow-up interview 2.5 years later indicated permanence of the result. Information was acquired from semi-structured retrospective interviews with a total duration of approximately eight hours. This case study may facilitate an improved understanding of the requirements for and the process of alleviating or resolving treatment-resistant depression with psychedelics. Recent clinical trials have utilized one or two doses of psilocybin. This case illustrates the need for adopting a multi-dose strategy over an extended period of time in order to achieve remission.