‘Equal-unblinding’ meta-analysis of psychedelic therapy vs. antidepressants for the treatment of depression
PsyArXiv – June 09, 2025
Source: PPR
Summary
For depression, new analysis suggests psychedelic therapy might significantly outperform antidepressants. Researchers combined multiple studies, carefully adjusting for how aware participants were of their treatment. Even accounting for this "unblinding" effect, psychedelic treatments demonstrated superior effectiveness. This highlights a promising, powerful new option for mental health treatment.
Abstract
‘Equal-unblinding’ meta-analysis of psychedelic therapy vs. antidepressants for the treatment of depression