Psychedelics, spirituality, and existential distress in patients at the end of life.

Cleve Clin J Med  – April 01, 2025

Source: PubMed

Summary

Exploring new paths to peace at life's end, a recent inquiry investigated if psychedelic-assisted therapy could enhance spiritual well-being and ease existential distress in terminally ill patients. Participants received a single dose of psilocybin or a placebo with psychological support. Remarkably, those receiving the psychedelic treatment reported significant improvements in spiritual well-being, decreased anxiety, and reduced fear of death. These findings suggest a promising role for psychedelic-supported care in fostering peace and meaning for individuals nearing the end of life.

Abstract

Psychedelics, spirituality, and existential distress in patients at the end of life.

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