Lasting effect of psilocybin on sociability can be blocked by DNA methyltransferase inhibition
OpenAlex – March 11, 2025
Source: OpenAlex
Summary
A single dose of Psilocybin durably enhanced social behavior in a mouse model of autism, a compelling finding for Psychology and Neuroscience. This lasting effect, explored within Psychedelics and Drug Studies, was blocked by inhibiting DNA methyltransferase I. This suggests an epigenetic mechanism involving DNA and Methyltransferase activity. The Chemistry and Pharmacology behind this Neurotransmitter Receptor Influence on Behavior highlight the therapeutic potential of such chemical synthesis and alkaloids, opening new avenues for understanding brain function.
Abstract
Abstract The recent renaissance in research on psychedelics such as psilocybin has highlighted their therapeutic potential including their lasting influences on brain function. Here we report that a single systemic administration of the serotonergic psychedelic psilocybin can durably promote social behaviour in the Cntnap2-knockout mouse model of autism. This effect can be blocked by pharmacological inhibition of DNA methyltransferase I, indicating an epigenetic mechanism underlying the long-lasting effect of psilocybin.