Exploring the potential of psychedelic-assisted psychotherapy for moral injury: A scoping review.
Progress in neuro-psychopharmacology & biological psychiatry – April 02, 2025
Source: PubMed
Summary
Psychedelic-assisted therapy shows promising results in treating moral injury - psychological trauma from events that violate one's core values. Studies examining MDMA, psilocybin, and LSD combined with psychotherapy reveal significant improvements in self-compassion, forgiveness, and PTSD symptoms. The treatments particularly help those struggling with trauma-related moral conflicts and self-acceptance.
Abstract
This scoping review addresses the need to comprehensively explore the potential of psychedelic-assisted psychotherapy (PAP) to facilitate recovery from moral injury. Moral injury (MI), characterized by profound psychological distress arising from morally challenging experiences, has garnered increased attention as a complex mental health concern with significant functional sequelae, especially in the context of post-traumatic stress disorder (PTSD). There is growing interest in exploring alternative therapeutic approaches, with psychedelics emerging as an exciting potential intervention, as moral injury impacts treatment resistance, suicidality, social isolation, and overall functioning. Ten studies were included from 11,734 publications. Studies utilized psilocybin, MDMA, or LSD. None focused specifically on moral injury. Diagnoses included PTSD, alcohol use disorder, insomnia, human Immunodeficiency virus-related demoralized men, barbiturate dependence, anxiety associated with life-threatening illness, major depression, and PTSD comorbid with generalized anxiety disorder, panic disorder, and borderline personality disorder. Studies reported rapid, increasing, and sustained self-compassion over time, alongside increases in self-forgiveness and self-acceptance, reduction in demoralization, and decreased drinking scores. Though in other diagnostic contexts, PAP has shown efficacy in addressing symptoms commonly associated with moral injury, particularly within the context of PTSD. It holds promise as an intervention for MI and requires further exploration.