[Subanesthetic Dose Ketamine Infusions for Treatment-Resistant Major Depression: An Application Protocol at a Public Hospital in Argentina].
Vertex (Buenos Aires, Argentina) – July 10, 2025
Source: PubMed
Summary
A public hospital has successfully implemented a new protocol offering rapid relief for severe depression unresponsive to conventional therapies. This involves carefully administered low-dose ketamine infusions, following international guidelines. The systematic approach ensures the treatment's effectiveness while prioritizing patient safety, providing a crucial option for those with persistent symptoms.
Abstract
Treatment-resistant major depression (TRD) poses a significant challenge in psychiatry due to the limited response to conventional therapies. Subanesthetic dose intravenous (IV) ketamine has emerged as an effective therapeutic option, providing rapid effects on depressive and suicidal symptoms. This article outlines the ketamine infusion protocol implemented in a general hospital, following international guidelines. Inclusion and exclusion criteria, dosage, administration procedure, and patient monitoring. Additionally, adverse effects and safety considerations. The implementation of this protocol optimizes the use of ketamine in TRD, ensuring both efficacy and safety.