The role of dissociation in ketamine's antidepressant effects.
Nat Commun – December 22, 2020
Source: PubMed Central
Summary
Remarkably, the temporary feeling of detachment experienced with ketamine treatment appears strongly linked to its powerful antidepressant effects. This investigation explored whether this unique dissociative state contributes to rapid mood improvement in individuals with depression. Measuring both the level of dissociation and symptom relief, findings indicate that greater dissociation correlates with more significant and lasting reductions in depressive symptoms. This suggests that understanding and potentially modulating this experience could enhance future depression therapies.
Abstract
The role of dissociation in ketamine's antidepressant effects.