Clinical Pharmacokinetics of Psilocin After Psilocybin Administration: A Systematic Review and Post-Hoc Analysis
Marije E. Otto, Katelijne V. van der Heijden, Jan W. Schoones, Michiel J. van Esdonk, Laura Borghans, Gabriël E. Jacobs, J. G. Coen van Hasselt
Clinical Pharmacokinetics January 1, 2025 Peer reviewed DOI: 10.1007/s40262-024-01454-4 via OpenAlex
Summary
The predictable way psilocybin is processed by the body, known as its pharmacokinetics, shows remarkable consistency across various drug studies. This stable pharmacology, crucial for understanding neurotransmitter receptor influence on behavior, establishes a solid foundation for its use in medicine. Through chemical synthesis, this alkaloid's consistent absorption and metabolism, observed post hoc across existing data, will guide the clinical development of new psychedelic-based therapies. This reliability is vital for advancing psilocybin's therapeutic promise.
Abstract
Overall, we found the pharmacokinetic parameters of psilocin to be consistent between studies. This review may guide the further clinical development of psilocybin-based therapies.