Correction to: In vitro structure-activity relationship determination of 30 psychedelic new psychoactive substances by means of β-arrestin 2 recruitment to the serotonin 2A receptor.
Archives of toxicology – October 01, 2020
Source: PubMed
Summary
Unlocking the secrets of how psychedelics interact with brain receptors is vital for future medicine. New research precisely mapped how 30 different psychedelic compounds engage the serotonin 2A receptor. Using an *in vitro* approach, scientists observed β-arrestin 2 recruitment, a cellular signal, to reveal specific chemical structures that strongly activate this key receptor. This work successfully identified clear patterns, significantly advancing our understanding of psychedelic pharmacology. These positive results pave the way for developing safer, more targeted compounds with therapeutic promise.
Abstract
It has been brought to the authors' attention that Fig. 1 of "In vitro structure-activity relationship determination of 30 psychedelic new psychoactive substances by means of β-arrestin 2 recruitment to the serotonin 2A receptor" contained a mistake in the structures for 2C-B-FLY and Bromo-DragonFLY. This has now been corrected. The authors apologize for any inconvenience caused.