Continuous flow synthesis of N,N-dimethyltryptamine (DMT) analogues with therapeutic potential.
RSC medicinal chemistry – October 07, 2024
Source: PubMed
Summary
Scientists have developed a more efficient way to produce DMT and similar compounds that show promise for treating mental health conditions. Using an innovative "continuous flow" technique, researchers created these compounds more safely and sustainably than traditional methods. The process also successfully produced rizatriptan, an existing migraine medication, demonstrating its practical value for pharmaceutical manufacturing.
Abstract
Herein, we describe the continuous flow synthesis and in-line extraction of N,N-dimethyltryptamine (DMT) and several of its analogues using a Fischer indole reaction, along with a larger gram scale synthesis (4.75 g) of the model compound. These products could then be quickly transformed into their respective fumarate salts, making them easier to handle and stable for long time storage using a straightforward batch procedure. Additionally, the commercially available drug rizatriptan benzoate could be synthesised with high purity using this setup. The presented method employs relatively green solvents both for the synthesis and purification of the target products.