Unexpected Serotonin Syndrome, Epileptic Seizures, and Cerebral Edema Following 2,5-dimethoxy-4-bromophenethylamine Ingestion.
Journal of forensic sciences – November 01, 2019
Source: PubMed
Summary
Unexpectedly severe brain damage can stem from recreational substances. An 18-year-old experienced severe serotonin syndrome and brain swelling after 2C-B intoxication, a designer drug. Routine screenings failed, but advanced forensic science confirmed this phenethylamine derivative. This finding highlights 2C-B's profound neurological risks, urging vital awareness for users and medical professionals.
Abstract
4-bromo-2,5-dimethoxyphenethylamine (2C-B) is a designer drug. In Europe, 2C-B is easily obtained and used for recreational purposes. It is known for its stimulating effects similar to those of 3,4-methylenedioxymethamphetamine, although in higher doses it has more hallucinogenic effects. Here, we report a case of 2C-B ingestion, confirmed by liquid chromatography-tandem mass spectrometry, in an 18-year-old man. The neurological consequences were severe, including the development of serotonin syndrome and severe brain edema. Supportive therapy resulted in a stable condition, although, after several months, the patient still suffered from severe neurological impairment due to the drug-induced toxicity. This case showed that 2C-B could not be identified with the drugs of abuse screening routinely used in Dutch hospitals. The use of 2C-B carries many risks, with potentially profound neurological damage, that both consumers and healthcare physicians are unaware of.