25I-NBOH: a new potent serotonin 5-HT2A receptor agonist identified in blotter paper seizures in Brazil.
Forensic toxicology – January 01, 2017
Source: PubMed
Summary
Forensic scientists successfully identified a new potent 5-HT2A receptor agonist, 25I-NBOH, found in blotter papers seized in Brazil. This novel psychoactive substance (NPS), one of many phenethylamine derivatives, posed a challenge as it fragmented during standard analysis. Advanced techniques like GC-MS and NMR were crucial for its full characterization, confirming it as nboh. This discovery marks the first scientific report of 25I-NBOH in actual seizures, aiding global monitoring efforts for these unregulated compounds.
Abstract
A new potent serotonin 5-HT2A receptor agonist was identified in blotter papers by several state level forensic laboratories in Brazil. The 25I-NBOH is a labile molecule, which fragments into 2C-I when analyzed by routine seized material screening gas chromatography (GC) methods. GC-mass spectrometry (MS), liquid chromatography-quadrupole time-of-flight-MS, and Fourier transform infrared and nuclear magnetic resonance analyses were performed to complete molecular characterization. Individual doses range from 300 to 1000 μg. Despite its being a potent 5-HT2A receptor agonist, 25I-NBOH is neither registered in the United Nations Office on Drugs and Crime (UNODC) nor classified as a scheduled substance in most countries. Sweden and Brazil seem to be the only countries to control 25I-NBOH. To our knowledge, this is the first scientific report dealing with identification of 25I-NBOH in actual seizures.