Bad trip due to 25I-NBOMe: a case report from the EU project SPICE II plus.
Clinical toxicology (Philadelphia, Pa.) – September 01, 2017
Source: PubMed
Summary
A unique case reveals how the body processes potent new psychoactive substances. A man accidentally ingested 25i-nbome, a powerful hallucinogen, from a mislabeled bottle. Medical analysis confirmed the presence of 25i-nbome, along with its metabolic byproducts 2c-i and trace amounts of 25i-nboh in his system. Despite severe initial symptoms, he recovered fully within hours. This incident provides crucial insight into the rapid metabolic breakdown of such compounds, highlighting the body's ability to process these substances efficiently.
Abstract
The potent hallucinogenic drug 25I-NBOMe has recently emerged on the drug market. We present a case with analytically confirmed 25I-NBOMe intoxication from the prospective study "SPICE II Plus". Because of a severe headache a 42-year-old man took one sip of a pediatric analgesic syrup, which had been refilled with a self-made solution of 25I-NBOMe in ethanol. Thirty minutes later restlessness occurred. On arrival in the emergency department mydriasis, strong sweating, disorientation, and agitation were noticed. Within short time the patient developed severe agitation, coenesthesia, and complex hallucinations. In blood serum samples obtained at admission revealed the presence of 25I-NBOMe (34 ng/mL), 2C-I (12 ng/mL) and 25I-NBOH (<1 ng/mL) (LC-ESI-MS/MS). The presumed analgesic syrup contained 25I-NBOMe (2800 μg/mL), and besides ethanol no other compounds were detected. After six hours, the symptoms resolved without further complications. This is a unique case of an analytically confirmed, accidental ingestion of 25I-NBOMe in a drug naïve adult. The finding of 2C-I in the serum sample 50 minutes after intake indicates a fast metabolic breakdown of 25I-NBOMe due to first-pass metabolism.