Default mode network dissociation in depressive and anxiety states
Brain Imaging and Behavior March 25, 2015 Joana Fernandes Coutinho, Sara Veiga Fernandesl, José Miguel Soares et al. 212 citations
Functional connectivity within the Default Mode Network (DMN) shows opposing patterns for anxiety and depression: increased connectivity in anterior regions (medial prefrontal cortex, anterior cingulate cortex) correlates with higher symptom scores, while posterior regions (involved in memory and perception) show decreased connectivity. This dissociation suggests functional specialization within the DMN for self-referential and emotional processes, contributing to understanding cognitive and affective alterations in depressive and anxiety states.